Finding Hormone Balance: Clinical Issues for Women
From puberty to menopause, women experience changes in their levels and ratios of sex hormones, including estrogen and progesterone. To complicate matters, estrogen is broken down to at least three types: estradiol, estrone, and estriol. Ultimately, estradiol and estrone are metabolized and converted into 2-hydroxyestrone (2-OH) - which confers weaker estrogenic activity-or 16a-hydroxyestrone (16a-OH), a more potent estrogen metabolite. The levels and ratios of hormones and their respective metabolites have a strong impact on women’s health.
Adrenal glands. The adrenal glands produce a small but significant amount of sex hormones and control the body’s energy output and ability to adapt to stress.
Liver. The liver plays an important role in the hydroxylation and excretion of estrogen and works to maintain healthy estrogen levels and estrogen metabolite balance.
Bone health. Estrogen, androgen, and progesterone play an important role in bone remodeling and maintaining healthy bone density.
Cardiovascular health. A decline in estrogen levels is strongly correlated with cardiovascular health concerns after the onset of menopause.
Reproductive health. Higher levels of progesterone are strongly associated with fertility and a healthy libido.
Breast health. A higher ratio of 2-OH to 16a-OH has been associated with enhanced breast health.
Mood and memory. The brain responds to hormones produced in the reproductive system, influencing mood, cognitive functioning, and a sense of well-being.
Body Composition. A decline in sex hormone levels can negatively impact body composition and fat distribution, causing an increase in centrally located adipose tissue.
Metagenics offers a comprehensive line of effective women’s health formulas for a variety of concerns.
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